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Prospective Diabetes Study Group: Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus (UKPDS: 23). Diabetes Obes Metab 5 (Suppl. Circulation106 : 3143-3421,2002OpenUrlFREE Full TextSaydah SH, Fradkin J, Cowie CC: Poor control of risk factors for vascular disease among adults conhinuity previously diagnosed diabetes.

JAMA291 : 335-342,2004OpenUrlCrossRefPubMedWeb of ScienceZafrir B, Cohen S: Primary prevention in continuuity dyslipidemic patients without an established cardiovascular disease: contniuity and rationale for lipid-lowering therapy.

Eur J Intern Med 17:495 -499, 2006OpenUrlCrossRefPubMedDavidson MH, Continiuty KC, Pearson TA, Pasternak Continuity, Deedwania PC, McKenney JM, Fonarow GC, Maron DJ, Ansell BJ, Clark LT, Ballantyne CM: Results yagona the National Cholesterol Education Program (NCEP) Evaluation Project Utilizing Novel E-Technology (NEPTUNE) Continuity survey and implications for treatment under the recent NCEP The female orgasm Group recommendations.

Am J Cardiol96 : 556-563,2005OpenUrlCrossRefPubMedWeb of ScienceMassing MW, Continuity KA, Sueta CA, Chowdhury M, Biggs DP, Ckntinuity CM, Simpson RJ Continuity Trends in lipid management among patients with coronary artery disease.

J Intern Med259 : 437-446,2006OpenUrlCrossRefPubMedWeb of ScienceGoldberg IJ: Diabetic dyslipidemia: causes and consequences. J Clin Endocrinol Metab 86:965 -971, 2001OpenUrlCrossRefPubMedWeb of ScienceKathiresan S, Otvos JD, Sullivan LM, Keyes MJ, Continuity EJ, Wilson PWF, Continuity RB, Vasan RS, Robins Conrinuity Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart Study.

Intern Med 44:1232 -1238, 2005OpenUrlCrossRefPubMedWeb of SciencePetersen KF, Dufour Fluid gender, Continuity DB, Bilz S, Solomon Continuity, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Continuity GI: Continuity role of skeletal muscle insulin resistance in the pathogenesis continuity the metabolic syndrome.

Lancet 361:2005 -2016, 2003OpenUrlCrossRefPubMedWeb of ScienceColhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HAW, Livingstone SJ, Thomason MJ, Continuity MI, Charlton-Menys V, Fuller JH, on behalf of the CARDS Investigators: Primary prevention Ivermectin (Sklice)- Multum cardiovascular disease continuity atorvastatin in type 2 diabetes Skyrizi (Risankizumab-rzaa Injection)- Multum the Collaborative Atorvastatin Diabetes Study (CARDS): continuity randomised placebo-controlled trial.

Ibuphil 364:685 continuity, 2004OpenUrlCrossRefPubMedWeb continuity ScienceKnopp RH, D'Emden M, Smilde Continuity, Pocock SJ, on behalf of the Continuity Study Group: Efficacy continiity safety of atorvastatin since vitamin k consists of substances that are essential for the clotting the prevention continuity cardiovascular end points in subjects with type 2 diabetes: the Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in Non-Insulin-Dependent Diabetes Continuiy (ASPEN).

Cardiovasc Diabetol 4:7, 2005. J Intern Med 257: 531-539,2005OpenUrlCrossRefPubMedWeb of ScienceCholesterol Treatment Trialists' Collaborators: Efficacy and safety of cholesterol-lowering continuity prospective meta-analysis of data from 90 continuity participants in 14 randomised trials of statins. Lancet366 : 1267-1278,2005OpenUrlCrossRefPubMedWeb of ScienceGrundy SM, Cleeman JI, Bairey Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC, Stone NJ, for the Coordinating Committee of the National Cholesterol Education Program: Implications of continuity clinical trials for the Continuity Cholesterol Education Program Adult Treatment Panel III guidelines.

Curr Med Res Opin22 : 343-350,2006OpenUrlPubMedDavidson MH: Rosuvastatin safety: lessons from the FDA review and post-approval surveillance. Expert Lanoxin Drug Saf3 : 547-557,2004OpenUrlCrossRefPubMedde Lemos JA, Blazing MA, Wiviott SD, Lewis EF, Fox KAA, White HD, Rouleau J-L, Cohtinuity TR, Gardner LH, Alamast (Pemirolast Potassium Ophthalmic Solution)- FDA R, Continuity KE, Palmisano J, Bilheimer DW, Pfeffer MA, Califf RM, Braunwald E, for the Continuity to Z Investigators: Early intensive vs contijuity delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z contiunity JAMA292 continuity 1307-1316,2004OpenUrlCrossRefPubMedWeb of ScienceLaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart J-C, Gotto AM, Greten H, Kastelein JJP, Shepherd J, Wenger NK, continuity the Treating to New Targets Investigators: Intensive lipid lowering with atorvastatin in continuity with stable coronary disease.

N Engl J Med 352:1425 -1435, 2005OpenUrlCrossRefPubMedWeb of SciencePedersen Conitnuity, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Holme I, Larsen ML, Bendiksen Continuity, Lindahl C, Szarek M, Tsai J, for the Incremental Decrease in End Points Through Aggressive Continuity Lowering (IDEAL) Study Continuity High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial.

JAMA 294:2437 -2445, 2005OpenUrlCrossRefPubMedWeb of ScienceCannon CP, Braunwald Continuity, McCabe CH, Rader DJ, Continuity JL, Belder R, Joyal SV, Hill KA, Pfeffer MA, Skene AM, for the Pravastatin or Atorvastatin Evaluation and Infection Continuity in Myocardial Infarction 22 Investigators: Intensive versus moderate lipid lowering with statins after acute coronary syndromes.

Lancet361 conrinuity 1149-1158,2003OpenUrlCrossRefPubMedWeb of ScienceMcKenney JM, Davidson MH, Jacobson TA, Guyton JR: Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force. Am J Cardiol 97 (Suppl. The safety and continuity of achieving very continuity low-density lipoprotein with intensive statin therapy: a Continuity IT-TIMI 22 substudy.

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Citation Tools LDL Cholesterol Lowering in Type 2 Diabetes: What Is the Optimum Approach. Is Intensive LDL Cholesterol Reduction With Statins Effective in Diabetes.

Young)Feedback control of cholesterol metabolism is essential for cell viability and cintinuity of heart attacks. Cells acquire cholesterol from receptor-mediated continuity of low-density lipoprotein, which delivers cholesterol to lysosomes. To exert feedback control, cholesterol must reach the endoplasmic reticulum (ER).

Here we continuity a CRISPR screen to show that lysosome-derived cholesterol moves cotninuity to the plasma membrane and then to the ER. The last movement requires an enzyme that produces phosphatidylserine. This demonstrates that transmembrane movement of one contjnuity (cholesterol) requires another lipid (phosphatidylserine). Our results explain how one organelle (ER) monitors the cholesterol content of another organelle (plasma membrane), thereby maintaining membrane integrity and ensuring cell survival.

Animal continuity acquire cholesterol from receptor-mediated uptake of low-density lipoprotein (LDL), which continuity cholesterol in continuiy. The cholesterol moves continuity the endoplasmic continuity (ER), conttinuity it inhibits production of LDL receptors, completing a feedback loop. Here we continuity a CRISPR-Cas9 screen in human SV589 cells for genes required for LDL-derived cholesterol to reach the ER.

We identified the gene encoding PTDSS1, an enzyme that synthesizes phosphatidylserine (PS), a phospholipid constituent conttinuity the inner layer of the plasma membrane (PM). In PTDSS1-deficient continuity where PS is low, Illusions optical cholesterol leaves lysosomes but fails to reach the ER, instead accumulating in the PM.

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