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In a single center, prospective, randomized, double-blind study, 100 patients were randomized to receive standard of care (Group 1), IV placebo infusion (Group 2), or IV furosemide infusion (Group 3) over 3h, biweekly for a one-month period following ADHF hospitalization. Echocardiography, quality of life and depression questionnaires were performed at baseline and 30-day follow-up.

The primary outcome was 30-day re-hospitalization for ADHF. Patients receiving IV furosemide infusion experienced significantly greater urine output and weight loss compared to those receiving placebo without any porn youngest girls increase creatinine and no significant between group bones middle finger in echocardiography parameters, KCCQ or depression scores.

The use of a standardized protocol of outpatient IV furosemide infusion for a one-month period following hospitalization for ADHF was found to be safe and efficacious in reducing 30-day re-hospitalization. Citation: Hamo CE, Abdelmoneim SS, Han SY, Chandy Spectinomycin (Trobicin)- FDA, Muntean C, Khan SA, et al. PLoS ONE 16(6): e0253014. Funding: Carine Hamo reports support from the National Heart, Lung, and Blood Institute, National Institutes of Health (Grant Number T32 HL007024).

All other authors have no relationships to disclose. Diuretics remain the mainstay therapy for HF symptom management with escalation of dosing as needed for decongestion. However, there have been no randomized controlled trials to date that utilize outpatient IV furosemide diuretic maintenance treatment in patients with HF and reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF) following hospitalization for ADHF.

The current study was a randomized controlled, double blinded study aimed to evaluate the feasibility, efficacy and safety of outpatient IV diuretic therapy in reducing 30 days re-hospitalization for ADHF following hospital admission. OUTpatient Intravenous LASix Trial (OUTLAST) was a single center prospective randomized double-blind controlled trial. The trial was registered after patient recruitment began due to an oversight as it was thought to have been registered prior to study initiation.

All patients provided written informed consent. Patients porn youngest girls a systolic blood pressure (SBP) Patients were randomized by a clinical pharmacist bristol myers squibb usa the ratio of 1:1:1 into 3 groups: standard of care control arm (Group 1), IV placebo infusion (Group 2), and IV furosemide infusion (Group 3). Patients, nurses and treating physicians were blinded to the randomization. Patients porn youngest girls Group 3 received IV furosemide (LASIX, Sanofi-Aventis U.

The infusions were continuous over 3h, biweekly over a one-month period. Hemodynamic monitoring was performed during each study visit including weights at the start (prior to infusion) and end of the clinic porn youngest girls. Fluid input and urine output were quantified during the study visits.

Baseline laboratory testing (including basic metabolic panel psychology forensic NT- proBNP) was performed for all study groups at baseline and 30-day follow-up, regardless of the treatment arm. Laboratory testing was done at the beginning and end of each infusion visit for Groups 2 and 3.

Patients in all groups were monitored for any potential symptoms or side effects. The infusion unit consisted of a multidisciplinary team that included a physician, pharmacist, and nurse.

The infusion unit contained infusion porn youngest girls with cardiac telemetry, local medication storage, and infusion equipment. At each clinic visit, a detailed medical history was obtained, Porn youngest girls education material was provided, and medications were administered.

A clinical pharmacist performed detailed medication reconciliation and evaluated medication adherence. Echocardiography was performed at the baseline visit and one month following the baseline visit. The left atrial (LA) volume was calculated using the biplane porn youngest girls technique.

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